Peptide Category: Growth Hormone
GDF-8 Propeptide
What is GDF-8 Propeptide? GDF-8 Propeptide is the naturally occurring inhibitory fragment derived from the precursor protein of myostatin, the growth and differentiation factor formally designated GDF-8. To understand what the propeptide is, you first need to understand how myostatin is produced. The myostatin gene encodes a large precursor protein called pre-pro-myostatin. After the signal
Mod GRF 1-29
What is Mod GRF 1-29 (CJC-1295 No DAC)? Mod GRF 1-29 — formally known as Modified Growth Hormone Releasing Factor 1-29, and commercially distributed under names including CJC-1295 Without DAC, CJC-1295 No DAC, and Sermorelin analogue — is a 29-amino-acid synthetic peptide derived from the first 29 amino acids of endogenous growth hormone-releasing hormone (GHRH).
Follistatin 344
What is Follistatin 344? Follistatin 344 is a 344-amino acid glycoprotein isoform of the broader follistatin family, a group of single-chain binding proteins first identified in the 1980s during research into reproductive hormone regulation. The “344” designation refers specifically to this isoform’s amino acid length, distinguishing it from the shorter Follistatin 288 variant, which lacks
GHRP-6
What is GHRP-6? GHRP-6 — Growth Hormone Releasing Peptide 6 — is a synthetic hexapeptide that was one of the first compounds ever developed specifically to stimulate endogenous growth hormone secretion. It was created in the early 1980s by Cyril Bowers and colleagues at Tulane University as part of a program to find small, orally
GHRP-2
What is GHRP-2? GHRP-2 (Growth Hormone Releasing Peptide 2) is a second-generation synthetic GH secretagogue that represents a significant iterative refinement over the original GHRPs developed in the 1980s. Its full chemical name is D-Ala-D-beta-Nal-Ala-Trp-D-Phe-Lys-NH2, and like its predecessor GHRP-6, it is a hexapeptide that acts as a potent agonist at the GHS-R1a (ghrelin receptor).
Hexarelin
What is Hexarelin? Hexarelin is a synthetic hexapeptide (His-D-2-MeTrp-Ala-Trp-D-Phe-Lys-NH2) developed in the late 1980s and early 1990s as part of a systematic effort to create orally or parenterally active growth hormone-releasing peptides (GHRPs). It belongs to the same peptide family as GHRP-2 and GHRP-6 but stands apart within that family for two distinctive properties: it
Tesamorelin
What is Tesamorelin? Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), the hypothalamic peptide that stimulates the pituitary gland to produce and secrete growth hormone. It is the active pharmaceutical ingredient in Egrifta, a prescription medication manufactured by Theratechnologies Inc. and approved by the U.S. Food and Drug Administration in November 2010 for
MK-677
What is MK-677 (Ibutamoren)? MK-677, also known by the nonproprietary name ibutamoren and sometimes referred to as ibutamoren mesylate, occupies an unusual position in the growth hormone secretagogue research space: it is not a peptide. Despite being frequently discussed alongside peptides like GHRP-2, GHRP-6, and ipamorelin, MK-677 is a small organic molecule — a spiropiperidine
Sermorelin
What is Sermorelin? Sermorelin is a synthetic analog of growth hormone-releasing hormone (GHRH), comprising the first 29 amino acids of the naturally occurring 44-amino acid GHRH peptide. It is the shortest N-terminal fragment of GHRH that retains full biological activity at the GHRH receptor, making it a compact and well-characterized tool compound for stimulating growth
Ipamorelin
What is Ipamorelin? Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) with the amino acid sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2, where Aib denotes alpha-aminoisobutyric acid and D-2-Nal denotes D-naphthylalanine at position 2. This five-residue sequence — among the shortest peptides known to produce meaningful GH secretagogue activity — was developed through systematic structure-activity relationship optimization at Novo